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Research suggests that for psychological reasons, some placebos are more effective than others. The brain has control over the body processes affected by placebos. For other uses, see Placebo (disambiguation) and Placebo effect (disambiguation). In conditioning, a neutral stimulus saccharin is paired in a drink with an agent that produces an unconditioned response. The placebo effect has sometimes been defined as a physiological effect caused by the placebo, but Moerman and Jonas have pointed out that this seems illogical, as a placebo is an inert substance that does not directly cause anything. The brain is also involved in less-studied ways upon nonanalgesic placebo effects. Such meaning is derived from the culture in which they live and which informs them about the nature of illness and how it responds to treatment.
Though the placebo effect is typically associated with deception in order to invoke positive expectations, studies carried out by Harvard Medical School have suggested that placebos can work even without deception. See also: Medical ethics and Philosophy of medicine. The higher brain works by regulating subcortical processes. In an attempt to implement placebos honestly, 80 patients suffering from IBS were divided into two groups, one of which receiving no treatment, while the other were provided with placebo pills. For more details on this topic, see neural top down control of physiology. Because the placebo response is simply the patient response that cannot be attributed to an investigational intervention, there are multiple possible components of a measured placebo effect. Because placebos are dependent upon perception and expectation, various factors that change the perception can increase the magnitude of the placebo response. The placebo effect has been controversial throughout history. For example, that agent might be cyclophosphamide, which causes immunosuppression.
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